Aortic Stenosis
Aortic
stenosis means that the aortic valve is too "narrow" or too "tight". There
are generally three causes of this problem.
- Congenital: Some
people are born with an abnormal valve where the valve has only
two leaflets instead of the normal three. This
bicuspid valve usually causes problems in younger patients, who
have had a heart murmur for many years.
- Calcific aortic stenosis occurs in older patients and is due to calcification that occurs
as we age.
- Rheumatic fever as a cause is becoming uncommon.
Symptoms
With
aortic stenosis, the left ventricle must pump blood against the
obstructed valve. Because of the strain on the ventricle,
the muscle becomes thickened, like a weightlifter's muscle. Over
time, there are usually three major symptoms that can develop.
- Shortness
of breath from heart failure.
- Chest pain from inadequate blood supply
to the thickened muscle.
- Blacking out spells from inadequate circulation
to the brain.
Diagnosis
Along
with the physical examination which reveals a murmur, the electrocardiogram
or ECG may show signs of strain on the heart.
- Echocardiogram. This ultrasound
picture of the heart can show the stenotic aortic valve and estimate the
pressure across aortic valve.
- Transesophageal echocardiograms can provide
even better pictures.
- Cardiac catheterization can reveal blockages
in the heart arteries and can directly measure the pressure across the aortic
valve. The
area of opening of the aortic valve can be measured or calculated
in a variety of ways. A normal aortic valve area is greater
than or equal to 2.0 cm2.
- Mild aortic stenosis: Valve area is between 1.5-2.0
cm2 with a pressure gradient of less than 25 mmHg
- Moderate aortic stenosis: Valve area is 1.0-1.5 cm2 with a
gradient of 25-40 mmHg
- Severe aortic
stenosis: Valve area is less than 1.0 cm2
and with a pressure gradient of greater than 40 mmHg
- Extremely severe: Valve area is less than 0.6 cm2 and the pressure gradient is more than
60 mmHg.
- Stress testing can be used to determine if an asymptomatic
patient will develop symptoms with significant exercise.
Medical Treatment
Patients
can go many years without having any symptoms from aortic stenosis,
but once symptoms develop, the chance of dying increases substantially. Death
can occur suddenly and without warning in some cases. In
addition, there really are no medicines that can treat this mechanical
valve problem. Observation is indicated generally only for
patients with no symptoms, and they must be followed carefully.
Surgical Treatment
- Indications: Surgery
is indicated in almost all patients with symptoms from aortic stenosis.
- Early Surgery: There
are some circumstances where surgery can be considered in a patient
with no symptoms:
- Asymptomatic patients with normal activity but who
develop symptoms with exercise testing. These patients are not
truly "asymptomatic".
- Patients with signs of deteriorating heart
function. Normally,
the heart can pump out around 50-60% of the blood within it. This
is called the ejection fraction. When the heart deteriorates,
the pumping ability decreases and the ejection fraction falls. If
the ejection fraction in a patient with aortic stenosis falls below
50%, this may be a time to consider surgery.
- Patients with severe
aortic stenosis if the valve appears to be rapidly calcifying on serial
examinations.
- Patients with extremely severe stenosis and the risk of
surgery for that patient is considered to be low.
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